Endocrine Abstracts

Introduction: Although involved in feeding and weight homeostasis, stimulation of pituitary GH secretion is the best established action of stomach-produced hormone ghrelin. However, its role in regulation of GH secretion is not yet clear. Some evidence indicates that circulating concentrations of GH and/or IGF-I could influence ghrelin levels. The pathophysiology of ghrelin secretion in acromegaly (specially aftar an oral glucose tolerance test (OGTT) is unclear.<p class="...

Introduction: MUTYH (MutY homolog Escherichia coli, homolog of MYH, hMYH) is a repair enzyme with a crucial role in the correction of DNA errors, being considered a protective factor of the cell. MUTYH mutations have been linked to MUTYH-associated polyposis syndrome (MAP), an autosomal recessive disorder characterized by multiple colorectal adenomas. Patients with MAP show a much higher lifetime risk of gastrointestinal cancers as an additional role of MUTYH, it appears to co...

Introduction: The number of transgender men and women who seek gender-affirming therapy is rapidly increasing worldwide. It is still a population at high risk for several morbidities. The Basque Country Gender Identity Clinic was created in 2009 to centralize their medical care in the region.Aim: To determine the proportion of transgender individuals in the Basque Country, the prevalence of several morbidities in this transgender population, their evolut...

Recent progress in surgical technology has resulted in new techniques as transoral endoscopic thyroidectomy (TOETVA) that is an option for patients’ cosmetic requests. We evaluated patients with thyroid cancer who underwent thyroidectomy by TOETVA approach and their follow-up. Retrospective study, 5 patients were included, Bethesda classification in FNAC resulted: 2 patients with VI category (CAT), 2: V CAT and 1: III CAT. All patients were operated by TOETVA between 2020...

Objective: The analysis of the copy number variation of CYP21A2 gene in a cohort of 21-hydroxylase deficiency (21-OHD) pediatric patients in a tertiary referral center from Romania.Methods: A total of 24 patients (21 female and 3 male, 7:1 female to male sex ratio) with previously biochemically and clinically diagnosed 21-OHD were enrolled in this study from October 2020 to October 2021. The age at the diagnosis was 4.6±4.8 years (mean&#177...

Background: Primary bilateral bilateral macronodular adrenal hyperplasia is a cause of Cushing’s syndrome. It is characterised by a large enlargement of the adrenal glands at the expense of multiple non-pigmented nodules. There is inefficient steroidogenesis.Summary of the case: A 58-year-old woman with a history of extreme obesity, type 2 diabetes mellitus, hypertension and dyslipidaemia was admitted to our hospital for cellulitis and anaemia secon...

Objective Vitamin D (VD) plays a role in immune response. Recent data shows that low levels of VD could worsen COVID-19 outcomes. This study aimed to establish an association between VD levels among COVID-19 patients with clinical outcomes and inflammatory markers.Methods Prospective multicentric cohort study. Consecutively recruitment. Patients were grouped according admission status and level of VD [sufficient >30 ng/ml (VDS), insufficient 20–...

Hypoparathyroidism is an endocrine deficiency whose substitution treatment with PTH 1-84 is only available in compassionate use in Argentina. There is a subgroup of patients in which the conventional therapy with calcium, calcitriol, phosphorous chelators, magnesium and diuretics does not reach an adequate clinical and/or biochemical compensation. Although teriparatide (PTH 1-34) is not approved for patients with hypoparathyroidism, it is a plausible therapeutic resource.<...

Warthin-like variant of papillary thyroid carcinoma is a rare histologic variant of PTC; they resemble Warthin tumor of salivary gland, frequently associated with lymphocytic thyroiditis. There is scarce literature available regarding this tumor.Clinical case: In August 2019 a 51-year-old female patient sought consult because she complained of constant pain in the anterior surface of the neck. Medical background: arterial hypertension, she had no history...

Patients with autoimmune thyroid diseases (AITDs) are likely to develop celiac disease (CD) among other autoimmune disorders. The prevalence of CD in general population is about 1–1.5% and the frequency of AITDs-CD association is about 1.2–4.8%. CD can be asymptomatic in adults. Our objectives were to determine the prevalence of CD in adult patients with AITDs and the presence of other endocrine and non-endocrine autoimmune diseases in a single center in Buenos Aires...